Full syllabus
All 120 slides, by module
Every slide in the masterclass, grouped into 7 modules. Select any title to open that slide.
Introduction20 slides
- 002Introduction to the Endocannabinoid SystemA conserved homeostatic network — and the most important physiological system most physicians have never been taught.
- 003Module 1 — Learning ObjectivesBy the end of this module, the learner will be able to:
- 004Why Every Physician Must Understand the ECSSix clinical reasons that survive any prohibitionist or promotional framing.
- 005ECS Discovery — A 60-Year Scientific JourneyFrom phytocannabinoid chemistry to receptor cloning to clinical translation.
- 006ECS Distribution — A System Present in Every OrganAnatomically widespread, phylogenetically conserved, and clinically relevant in every specialty.
- 007ECS: Three Core ComponentsReceptors, ligands, and enzymes — the irreducible architecture.
- 008ECS as the Body's Master Homeostatic RegulatorOne system that touches pain, mood, sleep, appetite, immunity, gut function, metabolism, and reproduction.
- 009ECS Compared to Other Cross-System Regulatory NetworksANS, HPA, RAAS, eicosanoids — and the missing fifth member of the family.
- 010The Educational Gap — Why ECS Is MissingA 30-year lag between scientific discovery and curricular inclusion.
- 011What ECS Education IS — and What It IS NOTDefining the scope of MBBS-level ECS teaching with clinical and academic discipline.
- 012India's Regulatory and Clinical ContextThe NDPS / AYUSH / consumer-product landscape and why physicians must understand it.
- 013Global ECS in Medical Education — A Comparative SnapshotHow nine countries currently handle (or fail to handle) ECS in undergraduate medical curricula.
- 014ECS Tone — A Clinical Concept Worth TeachingHow baseline endocannabinoid activity varies by tissue, by individual, and by disease state.
- 015Where ECS Sits in the MBBS Physiology FrameworkHow a 5–6 hour ECS module integrates seamlessly within existing physiology teaching — no new burden, no new subject.
- 016Clinical Bridge — A Patient Asks About CBD OilThe case vignette that operationalises every learning objective in this module.
- 017ECS Education Fits the CBME FrameworkWhy India's Competency-Based Medical Education framework is uniquely suited to ECS integration.
- 018ECS and India's Integrative Medicine StrengthWhy ECS science is uniquely positioned to bridge biomedicine and Ayurvedic phytotherapy.
- 019Module 1 — SummaryThe five points a physician must remember after this module.
- 020Module 1 — Self-AssessmentQuestion 1 of 6 in this CME assessment series.
- 021Proceeding to Module 2 — ECS ComponentsFrom architecture overview to molecular pharmacology of each component.
Components20 slides
- 022ECS ComponentsReceptors, ligands, and enzymes at molecular pharmacology depth.
- 023Module 2 — Learning ObjectivesBy the end of this module the learner will be able to:
- 024CB1 — The Primary CNS Cannabinoid ReceptorThe most abundant GPCR in the mammalian brain and the target of nearly every centrally-acting cannabinoid.
- 025CB2 — The Immune and Peripheral Cannabinoid ReceptorThe cannabinoid receptor that can be activated without producing psychoactivity.
- 026CB1 vs CB2 — Side-by-Side PharmacologyThe two cannabinoid receptors contrasted on every clinically relevant dimension.
- 027Anandamide (AEA) — The Bliss MoleculeThe first endocannabinoid identified, named from the Sanskrit ananda — bliss.
- 0282-Arachidonoylglycerol (2-AG) — The Primary Synaptic EndocannabinoidThe most abundant endocannabinoid in brain and the principal mediator of retrograde signalling.
- 029Synthesis Enzymes — NAPE-PLD and DAGLThe on-demand biosynthetic machinery that defines ECS as a 'made when needed' system.
- 030FAAH — Fatty Acid Amide HydrolaseThe primary enzyme degrading anandamide — and a major drug development target.
- 031MAGL — Monoacylglycerol LipaseThe principal 2-AG degrading enzyme and a dual anti-inflammatory drug target.
- 032ECS Enzyme Summary — Synthesis and DegradationThe four enzymes that define endocannabinoid tone.
- 033Retrograde Signalling — What Makes the ECS UniqueThe defining synaptic mechanism: a postsynaptic signal that travels backwards across the synapse.
- 034Non-Canonical ECS Targets — TRPV1, GPR55, PPAR-γ, 5-HT1AWhy cannabinoids do more than activate CB1 and CB2 — and why CBD's pleiotropy makes sense.
- 035Phytocannabinoids — Overview for Pharmacology TeachingMore than 100 compounds in Cannabis sativa — six matter clinically.
- 036Three Classes of Cannabinoid LigandsEndogenous, phytogenous, and synthetic — distinguished by origin, kinetics, and clinical implications.
- 037ECS Biochemical Pathway — Integrated FlowHow AEA and 2-AG biochemistry connect to membrane lipids and to eicosanoid signalling.
- 038ECS Ligand Profile — Quick ReferenceThe four most important ligands in clinical pharmacology, on one slide.
- 039Module 2 — SummaryThe molecular architecture of the ECS, distilled to six points.
- 040Module 2 — Self-AssessmentQuestion 2 of 6 in this CME assessment series.
- 041Proceeding to Module 3 — ECS PhysiologyFrom components to system-level homeostatic regulation.
Physiology19 slides
- 042ECS PhysiologyHomeostasis Across All Systems
- 043Module 3 — Learning ObjectivesLearning target: mechanism first, safety always, claims evidence-graded.
- 044ECS as Homeostatic Buffer — The Central Teaching ConceptECS acts at peripheral, spinal and brain levels of pain processing.
- 045ECS and Pain Modulation — Peripheral LevelMechanism does not equal indication: match every claim to its evidence level.
- 046ECS and Pain — Spinal and SupraspinalECS acts at peripheral, spinal and brain levels of pain processing.
- 047ECS and the HPA Stress AxisECS tone helps shape stress recovery, anxiety circuits and fear extinction.
- 048ECS and Sleep RegulationMechanism does not equal indication: match every claim to its evidence level.
- 049ECS and Appetite — Metabolic RegulationMechanism does not equal indication: match every claim to its evidence level.
- 050ECS and Immune Function — CB2 PhysiologyMechanism does not equal indication: match every claim to its evidence level.
- 051ECS in Gut-Brain AxisMechanism does not equal indication: match every claim to its evidence level.
- 052ECS and Reproductive PhysiologyThe practical MBBS outcome is safer counselling and risk recognition.
- 053ECS and the Nervous System — Neuroplasticity and CognitionThe practical MBBS outcome is safer counselling and risk recognition.
- 054The CED Hypothesis (Russo, 2004)Mechanism does not equal indication: match every claim to its evidence level.
- 055ECS Physiology — System-by-System Summary TableClose with the few points a physician must remember tomorrow.
- 056ECS and Neuroinflammation — The Bridge to PathologyMechanism does not equal indication: match every claim to its evidence level.
- 057ECS in Cardiovascular and Autonomic SystemsThe practical MBBS outcome is safer counselling and risk recognition.
- 058MODULE SUMMARYClose with the few points a physician must remember tomorrow.
- 059CME Self-AssessmentCME SELF-ASSESSMENT QUESTION
- 060Proceeding to Module 4:Close with the few points a physician must remember tomorrow.
Disease & Evidence14 slides
- 061ECS in DiseaseECS in Disease & Pathology
- 062Module 4 — Learning ObjectivesLearning target: mechanism first, safety always, claims evidence-graded.
- 063Evidence Grading Framework for ECS Clinical ClaimsMechanism does not equal indication: match every claim to its evidence level.
- 064Epilepsy — Strongest Clinical Evidence for ECS ModulationClose with the few points a physician must remember tomorrow.
- 065Chronic Pain — ECS Mechanisms and Clinical EvidenceMechanism does not equal indication: match every claim to its evidence level.
- 066Anxiety and Psychiatric Disorders — ECS EvidenceThe practical MBBS outcome is safer counselling and risk recognition.
- 067Neurodegenerative Diseases — Preclinical MechanismsThe practical MBBS outcome is safer counselling and risk recognition.
- 068Oncology — Teaching Within Strict BoundariesClose with the few points a physician must remember tomorrow.
- 069Approved Cannabinoid Medicines — Clinical ReferenceThe practical MBBS outcome is safer counselling and risk recognition.
- 070ECS in Disease — Evidence Level SummaryClose with the few points a physician must remember tomorrow.
- 071ECS in Metabolic DiseaseThe practical MBBS outcome is safer counselling and risk recognition.
- 072MODULE SUMMARYClose with the few points a physician must remember tomorrow.
- 073CME Self-AssessmentCME SELF-ASSESSMENT QUESTION
- 074Proceeding to Module 5:Close with the few points a physician must remember tomorrow.
Pharmacology & Safety14 slides
- 001First-Dose Safety, Psychosis Risk & Incremental TitrationClinical safety must be understood before product discussion: start low, go slow, reassess early, and step back immediately if red flags appear.
- 075Pharmacology & SafetyCannabinoid Pharmacology
- 076Module 5 — Learning ObjectivesLearning target: mechanism first, safety always, claims evidence-graded.
- 077GPCR Receptor Pharmacology — The FoundationThe practical MBBS outcome is safer counselling and risk recognition.
- 078Adverse Effects of Cannabinoids — By SystemThe practical MBBS outcome is safer counselling and risk recognition.
- 079Psychosis Risk — The Most Critical Safety TeachingThe practical MBBS outcome is safer counselling and risk recognition.
- 080CYP450 Drug Interactions — Critical for Safe PrescribingThe practical MBBS outcome is safer counselling and risk recognition.
- 081Special Populations — Safety FrameworkThe practical MBBS outcome is safer counselling and risk recognition.
- 082Cannabis Use Disorder — Pharmacological BasisTeach ECS as endogenous human physiology - not as a cannabis topic.
- 083Physician Counselling Framework — SAFE-ECSThe practical MBBS outcome is safer counselling and risk recognition.
- 084Cannabinoid Safety — Quick Reference CardThe practical MBBS outcome is safer counselling and risk recognition.
- 085MODULE SUMMARYClose with the few points a physician must remember tomorrow.
- 086CME Self-AssessmentCME SELF-ASSESSMENT QUESTION
- 087Proceeding to Module 6 — The Final Module:Close with the few points a physician must remember tomorrow.
Curriculum32 slides
- 088Curriculum & FutureCurriculum, Clinical Translation
- 089Module 6 — Learning ObjectivesLearning target: mechanism first, safety always, claims evidence-graded.
- 090MBBS Curriculum Blueprint — Phase and Subject MapFit ECS into existing subjects; no new burden, no undergraduate prescribing.
- 091ECS Competency Codes — CBME FrameworkOne central mechanism: postsynaptic feedback reduces presynaptic neurotransmitter release.
- 092Subject-by-Subject Integration LogicTeach ECS as endogenous human physiology - not as a cannabis topic.
- 093Assessment Blueprint — ECS Content Across MBBSFit ECS into existing subjects; no new burden, no undergraduate prescribing.
- 094Evidence-Language Control — What to Say and What NEVER to SayThe practical MBBS outcome is safer counselling and risk recognition.
- 095Safeguards Against Promotional MisuseClose with the few points a physician must remember tomorrow.
- 096NMC Implementation RoadmapFit ECS into existing subjects; no new burden, no undergraduate prescribing.
- 097Faculty Development CME — OutlineOne central mechanism: postsynaptic feedback reduces presynaptic neurotransmitter release.
- 098India's Leadership Opportunity — The National ArgumentMechanism does not equal indication: match every claim to its evidence level.
- 099Future Postgraduate ECS PathwayTeach ECS as endogenous human physiology - not as a cannabis topic.
- 100India ECS Research PrioritiesThe practical MBBS outcome is safer counselling and risk recognition.
- 101Global Comparison — Detailed Country AnalysisMechanism does not equal indication: match every claim to its evidence level.
- 102The NMC Proposal — Six Core DocumentsClose with the few points a physician must remember tomorrow.
- 103Addressing Anticipated NMC ConcernsMechanism does not equal indication: match every claim to its evidence level.
- 104ECS Education and Integrative MedicineMechanism does not equal indication: match every claim to its evidence level.
- 105Integrating ECS in Clinical Years — Reinforcement OnlyThe practical MBBS outcome is safer counselling and risk recognition.
- 106MODULE SUMMARYClose with the few points a physician must remember tomorrow.
- 107CME Self-AssessmentCME SELF-ASSESSMENT QUESTION
- 108Case Study: Implementing ECS at a Medical College — SimulationThe practical MBBS outcome is safer counselling and risk recognition.
- 109ECS and the Future of Pharmacology TeachingThe practical MBBS outcome is safer counselling and risk recognition.
- 110ECS Across the Patient Lifecycle — Teaching ContinuumThe practical MBBS outcome is safer counselling and risk recognition.
- 111ECS Education: What Success Looks LikeOne central mechanism: postsynaptic feedback reduces presynaptic neurotransmitter release.
- 112The ECS Argument in Three Minutes — Elevator PitchThe practical MBBS outcome is safer counselling and risk recognition.
- 113Frequently Asked Questions — Physician EditionThe practical MBBS outcome is safer counselling and risk recognition.
- 114ECS Research Landmarks — A Timeline for TeachingClose with the few points a physician must remember tomorrow.
- 115ECS Core Reference List for Faculty and StudentsThe practical MBBS outcome is safer counselling and risk recognition.
- 116CME Assessment — Final Comprehensive CheckClose with the few points a physician must remember tomorrow.
- 117ACADEMIC DISCLAIMERThe practical MBBS outcome is safer counselling and risk recognition.
- 118MODULE SUMMARYClose with the few points a physician must remember tomorrow.
- 119CME Self-AssessmentCME SELF-ASSESSMENT QUESTION
CME Complete1 slide
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